Assuntos
Doenças Negligenciadas/prevenção & controle , Dermatopatias/prevenção & controle , Anti-Infecciosos/administração & dosagem , Anti-Infecciosos/uso terapêutico , Agentes Comunitários de Saúde/educação , Atenção à Saúde , Política de Saúde , Humanos , Internacionalidade , Sistemas Automatizados de Assistência Junto ao Leito , Dermatopatias/classificação , Dermatopatias/diagnóstico , Dermatopatias/terapia , Medicina Tropical , VoluntáriosRESUMO
The structure of mycolactone E, isolated from the frog pathogen Mycobacterium liflandii, was established via organic synthesis. Within the mycolactone family of metabolites, a structural variation has been seen only at the unsaturated fatty acid moiety thus far, and mycolactone E follows this observation. Interestingly, the absolute configuration of its unsaturated fatty acid matches that of the mycolactones from human mycobacteria, rather than the structurally more closely related mycolactone F from fish mycobacteria.
Assuntos
Anuros/microbiologia , Ácidos Graxos Insaturados/química , Ácidos Graxos Insaturados/síntese química , Lactonas/química , Lactonas/síntese química , Mycobacterium/química , Animais , Ácidos Graxos Insaturados/isolamento & purificação , Humanos , Lactonas/isolamento & purificação , Espectroscopia de Ressonância Magnética , Espectrometria de Massas em TandemRESUMO
Buruli ulcer is a necrotizing skin disease caused by Mycobacterium ulcerans and associated with exposure to aquatic habitats. To assess possible transmission of M. ulcerans by aquatic biting insects, we conducted a field examination of biting water bugs (Hemiptera: Naucoridae, Belostomatidae, Nepidae) in 15 disease-endemic and 12 non-disease-endemic areas of Ghana, Africa. From collections of 22,832 invertebrates, we compared composition, abundance, and associated M. ulcerans positivity among sites. Biting hemipterans were rare and represented a small percentage (usually <2%) of invertebrate communities. No significant differences were found in hemipteran abundance or pathogen positivity between disease-endemic and non-disease-endemic sites, and between abundance of biting hemipterans and M. ulcerans positivity. Therefore, although infection through insect bites is possible, little field evidence supports the assumption that biting hemipterans are primary vectors of M. ulcerans.